Design of an injectable synthetic and biodegradable surgical biomaterial.

نویسندگان

  • Peter N Zawaneh
  • Sunil P Singh
  • Robert F Padera
  • Peter W Henderson
  • Jason A Spector
  • David Putnam
چکیده

We report the design of an injectable synthetic and biodegradable polymeric biomaterial comprised of polyethylene glycol and a polycarbonate of dihydroxyacetone (MPEG-pDHA). MPEG-pDHA is a thixotropic physically cross-linked hydrogel, displays rapid chain relaxation, is easily extruded through narrow-gauge needles, biodegrades into inert products, and is well tolerated by soft tissues. We demonstrate the clinical utility of MPEG-pDHA in the prevention of seroma, a common postoperative complication following ablative and reconstructive surgeries, in an animal model of radical breast mastectomy. This polymer holds significant promise for clinical applicability in a host of surgical procedures ranging from cosmetic surgery to cancer resection.

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عنوان ژورنال:
  • Proceedings of the National Academy of Sciences of the United States of America

دوره 107 24  شماره 

صفحات  -

تاریخ انتشار 2010